This is the airline's ninth UK base and its first in the UK for over a decade.
EasyJet already serves key domestic connections and international routes from Birmingham to beach and city destinations Amsterdam, Geneva, Milan, Naples, Lisbon, Faro and Palma de Mallorca. The addition of three more aircraft at the airport is enabling the airline to further expand its network from Birmingham with 16 new routes.
Johan Lundgren, Chief Executive of EasyJet, said:
"We are excited to open our newest base at Birmingham today, providing more choice, competition and connectivity as well as supporting over 1,200 jobs for the region.
"This base is enabling us to unlock the opportunity of the strong demand which exists for both leisure and business travel, as well as further grow our share of the package holiday market.
"We see much untapped potential at the airport providing the opportunity to grow further in future years."
EasyJet's passenger numbers at Birmingham are expected to be up nearly 60 percent this year versus last year.
Nick Barton, Chief Executive of Birmingham Airport (BHX), said:
"Today sees our growing partnership with easyJet reach new heights as the airline bases three aircraft here at Birmingham Airport. Customers can now take advantage of the airline's 16 new routes and have the flexibility of flight only or a full package holiday.
"easyJet has been a partner airline for 17 years. Its expansion here at Birmingham Airport is testament to the service, quality, price, reliability, and choice of destination that its customers have come to expect.
"We are looking forward to working with easyJet to further grow its destination list for our customers."
Andy Street, Mayor of the West Midlands, added:
"EasyJet's decision to set up this new base at BHX will be warmly welcomed by thousands of holidaymakers across the West Midlands and beyond.
"The increase in destinations is not only great news for those heading off to the sun this summer but also for our business community, helping them forge new overseas trade links.
"easyJet's decision is also a vote of confidence in Birmingham Airport and the people working in our aviation industry. The new base will support hundreds of jobs and help the airport to grow and thrive in the years ahead."